Chymorrhea » Selective Decontamination of Digestive Tract http://chymorrhea.wordpress.com "Craving for food is a constant and powerful stimulator of the gastric glands" Sun, 16 Nov 2008 04:49:53 +0000 http://wordpress.com/ en hourly 1 http://www.gravatar.com/blavatar/15e5bad3a9eb55923c2d5bd89f690b27?s=96&d=http://s.wordpress.com/i/buttonw-com.png Chymorrhea » Selective Decontamination of Digestive Tract http://chymorrhea.wordpress.com RCT shows reduction in mortality and acquisition of resistant bacteria in the ICU http://chymorrhea.wordpress.com/2008/03/30/rct-shows-reduction-in-mortality-and-acquisition-of-resistant-bacteria-in-the-icu/ http://chymorrhea.wordpress.com/2008/03/30/rct-shows-reduction-in-mortality-and-acquisition-of-resistant-bacteria-in-the-icu/#comments Sun, 30 Mar 2008 03:07:20 +0000 I.P. http://chymorrhea.wordpress.com/2008/03/30/rct-shows-reduction-in-mortality-and-acquisition-of-resistant-bacteria-in-the-icu/ ]]>

A large RCT convincingly proves that SDD reduces mortality and does not entail the emergence of resistant bacteria.

In the SDD group 69 (15%) patients died in the ICU compared with 107 (23%) in the control group (p=0.002). Hospital mortality was lower in the SDD groups than in the control group (113 [24%] vs 146 [31%], p=0.02). During their stay in intensive care, colonisation with gram-negative bacteria resistant to ceftazidime, ciprofloxacin, imipenem, polymyxin E, or tobramycin occurred in 61 (16%) of 378 SDD patients and in 104 (26%) of 395 patients in the control group (p=0.001). Colonisation with vancomycin-resistant enterococcus occurred in five (1%) SDD patients and in four (1%) controls (p=1.0). No patient in either group was colonised with meticillin-resistant Staphylococcus aureus. 

de Jonge et al. Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. The Lancet 2003; 362:1011-1016

 

DOI:10.1016/S0140-6736(03)14409-1

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